| 09/03/05 | at | Maryville | 31-28 |
| 09/10/05 | hosting | Wesley | 9-49 |
| 09/17/05 | at | Guilford | 28-21 |
| 10/01/05 | at | Ferrum | 40-55 |
| 10/08/05 | hosting | Methodist | 28-29 |
| 10/15/05 | hosting | North Carolina Wesleyan | 39-32 |
| 10/22/05 | at | Greensboro | 21-20 |
| 10/29/05 | hosting | Shenandoah | 51-19 |
| 11/05/05 | hosting | Christopher Newport | 38-30 |
| 11/12/05 | at | Chowan | 60-32 |