| 09/03/05 | at | SMU | 28-23 |
| 09/10/05 | hosting | Samford | 48-14 |
| 09/17/05 | at | Army | 20-10 |
| 10/01/05 | at | Texas A&M | 13-16 OT |
| 10/08/05 | at | Iowa State | 23-13 |
| 10/15/05 | hosting | Nebraska | 14-23 |
| 10/22/05 | at | Oklahoma | 30-37 2OT |
| 10/29/05 | hosting | Texas Tech | 0-28 |
| 11/05/05 | hosting | Texas | 0-62 |
| 11/12/05 | at | Missouri | 16-31 |
| 11/19/05 | hosting | Oklahoma State | 44-34 |