| 08/25/05 | at | Missouri Western | 7-26 |
| 09/03/05 | at | Abilene Christian | 49-37 |
| 09/10/05 | hosting | West Texas A&M | 31-44 |
| 09/17/05 | at | Angelo St | 16-20 |
| 09/24/05 | at | TAMU-Commerce | 3-17 |
| 10/01/05 | hosting | SW Oklahoma St | 37-20 |
| 10/08/05 | hosting | TAMU-Kingsville | 38-41 |
| 10/15/05 | at | East Central OK | 39-42 |
| 10/29/05 | at | SE Oklahoma St | 24-31 |
| 11/05/05 | hosting | Northeastern St OK | 37-10 |