| 09/01/05 | at | South Carolina | 15-24 |
| 09/17/05 | at | South Florida | 14-31 |
| 09/24/05 | hosting | Marshall | 23-13 |
| 10/01/05 | at | Louisiana-Lafayette | 24-21 |
| 10/08/05 | hosting | Memphis | 38-17 |
| 10/15/05 | at | Southern Miss | 31-52 |
| 10/21/05 | hosting | Tulane | 34-24 |
| 10/29/05 | at | East Carolina | 30-20 |
| 11/05/05 | hosting | Houston | 31-29 |
| 11/12/05 | at | Alabama-Birmingham | 27-21 |
| 11/19/05 | at | Rice | 31-28 |
| 12/03/05 | hosting | Tulsa | 27-44 |
| 12/24/05 | vs. | Nevada | 48-49 OT |