| 09/10/05 | at | North Park | 14-19 |
| 09/17/05 | hosting | Elmhurst | 17-21 |
| 09/24/05 | at | Illinois Wesleyan | 13-20 |
| 10/01/05 | at | DePauw | 9-33 |
| 10/08/05 | at | Washington U. | 27-0 |
| 10/15/05 | hosting | Carnegie Mellon | 35-6 |
| 10/29/05 | at | Bethany WV | 42-3 |
| 11/05/05 | hosting | Case Western Reserve | 14-7 |
| 11/12/05 | hosting | Eureka | 55-7 |