| 09/01/05 | hosting | Buffalo | 38-0 |
| 09/10/05 | hosting | Liberty | 59-0 |
| 09/17/05 | at | Georgia Tech | 13-28 |
| 10/01/05 | at | Army | 47-13 |
| 10/07/05 | hosting | Syracuse | 26-7 |
| 10/15/05 | at | Cincinnati | 17-28 |
| 10/22/05 | hosting | Rutgers | 24-26 |
| 11/02/05 | at | West Virginia | 13-45 |
| 11/12/05 | at | Pittsburgh | 0-24 |
| 11/26/05 | hosting | South Florida | 15-10 |
| 12/03/05 | hosting | Louisville | 20-30 |