| 09/03/05 | hosting | Duke | 24-21 |
| 09/17/05 | at | Wake Forest | 34-44 |
| 09/24/05 | at | West Virginia | 15-20 |
| 10/01/05 | hosting | Southern Miss | 7-33 |
| 10/08/05 | hosting | Rice | 41-28 |
| 10/15/05 | at | SMU | 24-17 |
| 10/22/05 | at | Memphis | 24-27 |
| 10/29/05 | hosting | Central Florida | 20-30 |
| 11/12/05 | at | Tulsa | 13-45 |
| 11/19/05 | at | Marshall | 34-29 |
| 11/26/05 | hosting | Alabama-Birmingham | 31-23 |