| 09/01/05 | at | Cincinnati | 26-28 |
| 09/10/05 | hosting | Louisiana-Lafayette | 31-10 |
| 09/17/05 | at | Michigan | 0-55 |
| 09/24/05 | at | Central Michigan | 23-20 OT |
| 10/01/05 | hosting | Kent St | 27-20 |
| 10/08/05 | at | Toledo | 3-30 |
| 10/15/05 | at | Northern Illinois | 8-24 |
| 10/22/05 | hosting | Miami OH | 23-24 |
| 11/05/05 | hosting | Western Michigan | 36-44 |
| 11/12/05 | hosting | Ball State | 25-26 |
| 11/19/05 | at | Buffalo | 38-14 |