| 08/27/05 | hosting | Virginia Union | 53-26 |
| 09/03/05 | at | Presbyterian | 6-35 |
| 09/10/05 | hosting | Elizabeth City St | 39-6 |
| 09/17/05 | vs. | St Paul's | 23-13 |
| 09/24/05 | hosting | Virginia St | 14-22 |
| 10/01/05 | hosting | Winston-Salem St | 24-26 |
| 10/08/05 | at | North Carolina Central | 12-17 |
| 10/15/05 | hosting | Johnson C. Smith | 34-23 |
| 10/22/05 | at | St Augustine's | 45-28 |
| 10/29/05 | hosting | Livingstone | 52-22 |