| 09/03/05 | at | Iowa State | 21-32 |
| 09/10/05 | hosting | Drake | 56-19 |
| 09/17/05 | at | Eastern Illinois | 27-6 |
| 09/24/05 | hosting | Murray State | 42-0 |
| 10/01/05 | at | Youngstown St | 17-20 |
| 10/08/05 | hosting | Western Kentucky | 34-37 |
| 10/15/05 | at | Southern Illinois | 61-35 |
| 10/22/05 | hosting | Northern Iowa | 38-3 |
| 10/29/05 | hosting | Western Illinois | 17-31 |
| 11/05/05 | at | Missouri St | 48-23 |
| 11/12/05 | hosting | Indiana State | 70-28 |