| 09/02/05 | at | Central Michigan | 20-13 |
| 09/10/05 | hosting | Nicholls State | 35-31 |
| 09/17/05 | hosting | Kentucky | 38-14 |
| 10/01/05 | at | Wisconsin | 24-41 |
| 10/08/05 | hosting | Illinois | 36-13 |
| 10/15/05 | at | Iowa | 21-38 |
| 10/22/05 | hosting | Ohio State | 10-41 |
| 10/29/05 | at | Michigan State | 15-46 |
| 11/05/05 | hosting | Minnesota | 21-42 |
| 11/12/05 | at | Michigan | 14-41 |
| 11/19/05 | hosting | Purdue | 14-41 |