| 09/03/05 | hosting | Illinois St | 32-21 |
| 09/10/05 | hosting | Iowa | 23-3 |
| 09/23/05 | at | Army | 28-21 |
| 10/01/05 | at | Nebraska | 20-27 2OT |
| 10/08/05 | hosting | Baylor | 13-23 |
| 10/15/05 | at | Missouri | 24-27 OT |
| 10/22/05 | hosting | Oklahoma State | 37-10 |
| 10/29/05 | at | Texas A&M | 42-14 |
| 11/05/05 | hosting | Kansas St | 45-17 |
| 11/12/05 | hosting | Colorado | 30-16 |
| 11/26/05 | at | Kansas | 21-24 OT |
| 12/31/05 | vs. | TCU | 24-27 |