| 09/03/05 | hosting | Florida Atlantic | 30-19 |
| 09/10/05 | hosting | Appalachian State | 36-8 |
| 09/17/05 | hosting | Louisiana Tech | 34-14 |
| 10/01/05 | at | Texas Tech | 17-30 |
| 10/08/05 | at | Kansas St | 3-12 |
| 10/15/05 | vs. | Oklahoma | 3-19 |
| 10/22/05 | at | Colorado | 13-44 |
| 10/29/05 | hosting | Missouri | 13-3 |
| 11/05/05 | hosting | Nebraska | 40-15 |
| 11/12/05 | at | Texas | 14-66 |
| 11/26/05 | hosting | Iowa State | 24-21 OT |
| 12/23/05 | vs. | Houston | 42-13 |