| 09/10/05 | hosting | Cumberland KY | 21-28 |
| 09/17/05 | hosting | St Xavier | 14-37 |
| 09/24/05 | at | St Francis IL | 34-27 |
| 10/01/05 | hosting | Walsh | 16-34 |
| 10/08/05 | at | Geneva | 15-14 |
| 10/15/05 | hosting | Ohio Dominican | 13-27 |
| 10/22/05 | at | Urbana | 34-42 |
| 10/29/05 | hosting | St Francis IN | 7-28 |
| 11/05/05 | hosting | Taylor | 34-32 |
| 11/12/05 | at | Quincy | 9-48 |