| 09/03/05 | vs. | Navy | 23-20 |
| 09/10/05 | hosting | Clemson | 24-28 |
| 09/17/05 | hosting | West Virginia | 19-31 |
| 09/24/05 | at | Wake Forest | 22-12 |
| 10/01/05 | hosting | Virginia | 45-33 |
| 10/08/05 | at | Temple | 38-7 |
| 10/20/05 | hosting | Virginia Tech | 9-28 |
| 10/29/05 | at | Florida State | 27-35 |
| 11/12/05 | at | North Carolina | 33-30 OT |
| 11/19/05 | hosting | Boston College | 16-31 |
| 11/26/05 | at | North Carolina State | 14-20 |