| 09/03/05 | at | Bridgewater VA | 36-35 |
| 09/10/05 | at | Seton Hill | 28-9 |
| 09/17/05 | hosting | Catholic | 37-36 |
| 10/01/05 | hosting | Ursinus | 28-20 |
| 10/08/05 | at | Gettysburg | 17-20 |
| 10/15/05 | at | Dickinson | 22-25 |
| 10/22/05 | at | Randolph-Macon | 10-34 |
| 10/29/05 | hosting | Franklin & Marshall | 14-17 |
| 11/05/05 | at | Muhlenberg | 13-6 |
| 11/12/05 | hosting | Johns Hopkins | 5-14 |