| 09/05/05 | hosting | Mississippi | 6-10 |
| 09/17/05 | hosting | Chattanooga | 59-14 |
| 09/24/05 | at | Tulsa | 31-37 OT |
| 10/01/05 | hosting | UTEP | 27-20 |
| 10/08/05 | at | Central Florida | 17-38 |
| 10/15/05 | at | Houston | 35-20 |
| 10/22/05 | hosting | East Carolina | 27-24 |
| 11/01/05 | hosting | Alabama-Birmingham | 20-37 |
| 11/12/05 | at | Tennessee | 16-20 |
| 11/19/05 | at | Southern Miss | 24-22 |
| 11/26/05 | hosting | Marshall | 26-3 |
| 12/26/05 | vs. | Akron | 38-31 |