| 09/03/05 | at | Ohio State | 14-34 |
| 09/10/05 | hosting | Central Michigan | 37-38 |
| 09/17/05 | at | Kent St | 27-10 |
| 09/28/05 | hosting | Cincinnati | 44-16 |
| 10/05/05 | at | Northern Illinois | 27-38 |
| 10/15/05 | hosting | Akron | 51-23 |
| 10/22/05 | at | Eastern Michigan | 24-23 |
| 10/29/05 | at | Temple | 41-14 |
| 11/05/05 | hosting | Buffalo | 54-13 |
| 11/15/05 | hosting | Bowling Green | 14-42 |
| 11/21/05 | at | Ohio U. | 38-7 |