| 09/05/05 | at | Florida State | 7-10 |
| 09/17/05 | at | Clemson | 36-30 OT |
| 09/24/05 | hosting | Colorado | 23-3 |
| 10/01/05 | hosting | South Florida | 27-7 |
| 10/08/05 | hosting | Duke | 52-7 |
| 10/15/05 | at | Temple | 34-3 |
| 10/29/05 | hosting | North Carolina | 34-16 |
| 11/05/05 | at | Virginia Tech | 27-7 |
| 11/12/05 | at | Wake Forest | 47-17 |
| 11/19/05 | hosting | Georgia Tech | 10-14 |
| 11/26/05 | hosting | Virginia | 25-17 |
| 12/30/05 | vs. | LSU | 3-40 |