| 09/03/05 | hosting | Northern Illinois | 33-17 |
| 09/10/05 | hosting | Notre Dame | 10-17 |
| 09/17/05 | hosting | Eastern Michigan | 55-0 |
| 09/24/05 | at | Wisconsin | 20-23 |
| 10/01/05 | at | Michigan State | 34-31 OT |
| 10/08/05 | hosting | Minnesota | 20-23 |
| 10/15/05 | hosting | Penn State | 27-25 |
| 10/22/05 | at | Iowa | 23-20 OT |
| 10/29/05 | at | Northwestern | 33-17 |
| 11/12/05 | hosting | Indiana | 41-14 |
| 11/19/05 | hosting | Ohio State | 21-25 |
| 12/28/05 | vs. | Nebraska | 28-32 |