| 09/03/05 | hosting | Kent St | 49-14 |
| 09/10/05 | hosting | Hawai`i | 42-14 |
| 09/17/05 | at | Notre Dame | 44-41 OT |
| 09/24/05 | at | Illinois | 61-14 |
| 10/01/05 | hosting | Michigan | 31-34 OT |
| 10/15/05 | at | Ohio State | 24-35 |
| 10/22/05 | hosting | Northwestern | 14-49 |
| 10/29/05 | hosting | Indiana | 46-15 |
| 11/05/05 | at | Purdue | 21-28 |
| 11/12/05 | at | Minnesota | 18-41 |
| 11/19/05 | hosting | Penn State | 22-31 |