| 09/03/05 | hosting | SW Oklahoma St | 49-0 |
| 09/10/05 | at | TAMU-Commerce | 25-27 |
| 09/17/05 | hosting | SE Oklahoma St | 24-17 |
| 09/24/05 | at | Angelo St | 29-30 |
| 10/01/05 | hosting | West Texas A&M | 44-47 |
| 10/08/05 | at | Tarleton St | 7-37 |
| 10/15/05 | hosting | TAMU-Kingsville | 41-14 |
| 10/22/05 | hosting | East Central OK | 42-31 |
| 10/29/05 | at | Eastern New Mexico | 62-27 |
| 11/05/05 | hosting | Abilene Christian | 35-30 |