| 09/01/05 | at | Tulsa | 41-10 |
| 09/10/05 | hosting | Colorado State | 56-24 |
| 09/17/05 | hosting | Florida Atlantic | 46-7 |
| 09/24/05 | hosting | Purdue | 42-35 2OT |
| 10/01/05 | at | Penn State | 14-44 |
| 10/08/05 | at | Michigan | 23-20 |
| 10/15/05 | hosting | Wisconsin | 34-38 |
| 10/29/05 | hosting | Ohio State | 31-45 |
| 11/05/05 | at | Indiana | 42-21 |
| 11/12/05 | hosting | Michigan State | 41-18 |
| 11/19/05 | at | Iowa | 28-52 |
| 12/30/05 | vs. | Virginia | 31-34 |