| 09/03/05 | vs. | Arkansas State | 44-17 |
| 09/10/05 | hosting | New Mexico | 35-45 |
| 09/17/05 | hosting | Troy | 52-21 |
| 10/01/05 | hosting | Texas | 20-51 |
| 10/08/05 | at | Oklahoma State | 38-31 |
| 10/15/05 | hosting | Iowa State | 27-24 OT |
| 10/22/05 | hosting | Nebraska | 41-24 |
| 10/29/05 | at | Kansas | 3-13 |
| 11/05/05 | at | Colorado | 12-41 |
| 11/12/05 | hosting | Baylor | 31-16 |
| 11/19/05 | at | Kansas St | 28-36 |
| 12/30/05 | vs. | South Carolina | 38-31 |