| 09/03/05 | hosting | Maine | 25-7 |
| 09/10/05 | hosting | Wake Forest | 31-3 |
| 09/17/05 | hosting | Pittsburgh | 7-6 |
| 10/01/05 | hosting | Iowa State | 27-20 2OT |
| 10/08/05 | hosting | Texas Tech | 31-34 |
| 10/15/05 | at | Baylor | 23-14 |
| 10/22/05 | at | Missouri | 24-41 |
| 10/29/05 | hosting | Oklahoma | 24-31 |
| 11/05/05 | at | Kansas | 15-40 |
| 11/12/05 | hosting | Kansas St | 27-25 |
| 11/25/05 | at | Colorado | 30-3 |
| 12/28/05 | vs. | Michigan | 32-28 |