| 09/03/05 | hosting | Ohio U. | 38-14 |
| 09/10/05 | hosting | Northern Illinois | 38-37 |
| 09/17/05 | at | Arizona State | 21-52 |
| 09/24/05 | hosting | Penn State | 29-34 |
| 10/08/05 | hosting | Wisconsin | 51-48 |
| 10/15/05 | at | Purdue | 34-29 |
| 10/22/05 | at | Michigan State | 49-14 |
| 10/29/05 | hosting | Michigan | 17-33 |
| 11/05/05 | hosting | Iowa | 28-27 |
| 11/12/05 | at | Ohio State | 7-48 |
| 11/19/05 | at | Illinois | 38-21 |
| 12/30/05 | vs. | UCLA | 0.4777402119728155 |