| 09/03/05 | at | Michigan | 17-33 |
| 09/10/05 | at | Northwestern | 37-38 |
| 09/17/05 | hosting | Tennessee Tech | 42-3 |
| 09/24/05 | at | Akron | 42-48 OT |
| 10/05/05 | hosting | Miami OH | 38-27 |
| 10/15/05 | hosting | Eastern Michigan | 24-8 |
| 10/22/05 | at | Kent St | 34-3 |
| 10/29/05 | hosting | Ball State | 17-31 |
| 11/05/05 | at | Central Michigan | 31-28 |
| 11/16/05 | at | Toledo | 35-17 |
| 11/23/05 | hosting | Western Michigan | 42-7 |
| 12/01/05 | vs. | Akron | 30-31 |