| 09/03/05 | hosting | South Florida | 23-13 |
| 09/10/05 | hosting | Cincinnati | 42-24 |
| 09/17/05 | hosting | Central Michigan | 40-3 |
| 09/24/05 | at | Northwestern | 34-29 |
| 10/01/05 | hosting | Minnesota | 44-14 |
| 10/08/05 | hosting | Ohio State | 17-10 |
| 10/15/05 | at | Michigan | 25-27 |
| 10/22/05 | at | Illinois | 63-10 |
| 10/29/05 | hosting | Purdue | 33-15 |
| 11/05/05 | hosting | Wisconsin | 35-14 |
| 11/19/05 | at | Michigan State | 31-22 |
| 01/03/06 | vs. | Florida State | 26-23 3OT |