| 09/03/05 | hosting | Notre Dame | 21-42 |
| 09/09/05 | at | Ohio U. | 10-16 OT |
| 09/17/05 | at | Nebraska | 6-7 |
| 09/24/05 | hosting | Youngstown St | 41-0 |
| 09/30/05 | at | Rutgers | 29-37 |
| 10/08/05 | hosting | Cincinnati | 38-20 |
| 10/15/05 | hosting | South Florida | 31-17 |
| 10/22/05 | hosting | Syracuse | 34-17 |
| 11/03/05 | at | Louisville | 20-42 |
| 11/12/05 | hosting | Connecticut | 24-0 |
| 11/24/05 | at | West Virginia | 13-45 |