| 09/03/05 | at | Eastern New Mexico | 28-12 |
| 09/10/05 | hosting | Angelo St | 24-27 |
| 09/17/05 | at | Midwestern St | 17-24 |
| 09/24/05 | at | Panhandle St | 35-3 |
| 10/01/05 | hosting | Abilene Christian | 42-24 |
| 10/08/05 | at | Northeastern St OK | 49-32 |
| 10/15/05 | hosting | TAMU-Commerce | 24-23 |
| 10/22/05 | at | SW Oklahoma St | 43-12 |
| 10/29/05 | hosting | Central Oklahoma | 31-24 |
| 11/05/05 | at | East Central OK | 21-17 |