| 09/10/05 | at | Alabama | 21-30 |
| 09/17/05 | hosting | McNeese State | 48-20 |
| 10/01/05 | at | East Carolina | 33-7 |
| 10/08/05 | hosting | Tulsa | 17-34 |
| 10/15/05 | hosting | Central Florida | 52-31 |
| 10/21/05 | at | Alabama-Birmingham | 37-28 |
| 10/29/05 | at | North Carolina State | 17-21 |
| 11/08/05 | at | Marshall | 27-24 OT |
| 11/13/05 | at | Houston | 24-27 |
| 11/19/05 | hosting | Memphis | 22-24 |
| 11/26/05 | hosting | Tulane | 26-7 |
| 12/20/05 | vs. | Arkansas State | 0.7642638604358262 |