| 09/03/05 | hosting | Louisiana-Lafayette | 60-3 |
| 09/10/05 | at | Ohio State | 25-22 |
| 09/17/05 | hosting | Rice | 51-10 |
| 10/01/05 | at | Missouri | 51-20 |
| 10/08/05 | vs. | Oklahoma | 45-12 |
| 10/15/05 | hosting | Colorado | 42-17 |
| 10/22/05 | hosting | Texas Tech | 52-17 |
| 10/29/05 | at | Oklahoma State | 47-28 |
| 11/05/05 | at | Baylor | 62-0 |
| 11/12/05 | hosting | Kansas | 66-14 |
| 11/25/05 | at | Texas A&M | 40-29 |
| 12/03/05 | vs. | Colorado | 70-3 |
| 01/04/06 | vs. | Southern Cal | 0.4418600026216779 |