| 09/01/05 | hosting | Minnesota | 10-41 |
| 09/10/05 | at | Oklahoma | 15-31 |
| 09/17/05 | at | North Texas | 54-2 |
| 09/24/05 | hosting | Memphis | 37-31 OT |
| 10/01/05 | hosting | Houston | 23-30 |
| 10/08/05 | at | Southern Miss | 34-17 |
| 10/15/05 | at | Rice | 41-21 |
| 10/22/05 | hosting | SMU | 20-13 |
| 11/05/05 | at | UTEP | 38-41 |
| 11/12/05 | hosting | East Carolina | 45-13 |
| 11/19/05 | vs. | Tulane | 38-14 |
| 12/03/05 | at | Central Florida | 44-27 |
| 12/31/05 | vs. | Fresno State | 0.4520702475321609 |