| 09/03/05 | at | San Diego State | 44-21 |
| 09/10/05 | hosting | Rice | 63-21 |
| 09/17/05 | hosting | Oklahoma | 41-24 |
| 10/01/05 | hosting | Washington | 21-17 |
| 10/08/05 | hosting | California | 47-40 |
| 10/15/05 | at | Washington State | 44-41 OT |
| 10/22/05 | hosting | Oregon State | 51-28 |
| 10/29/05 | at | Stanford | 30-27 OT |
| 11/05/05 | at | Arizona | 14-52 |
| 11/12/05 | hosting | Arizona State | 45-35 |
| 12/03/05 | at | Southern Cal | 19-66 |
| 12/30/05 | vs. | Northwestern | 0.5222597880271844 |