| 09/03/05 | at | New Mexico State | 34-17 |
| 09/16/05 | hosting | Houston | 44-41 OT |
| 09/24/05 | hosting | New Mexico | 21-13 |
| 10/01/05 | at | Memphis | 20-27 |
| 10/14/05 | vs. | Tulane | 45-21 |
| 10/22/05 | hosting | Marshall | 31-3 |
| 10/29/05 | at | Rice | 38-31 |
| 11/05/05 | hosting | Tulsa | 41-38 |
| 11/12/05 | hosting | Texas Southern | 45-0 |
| 11/19/05 | hosting | Alabama-Birmingham | 23-35 |
| 11/26/05 | at | SMU | 27-40 |
| 12/21/05 | vs. | Toledo | 0.40663819304627524 |