| 09/01/05 | hosting | Vanderbilt | 20-24 |
| 09/10/05 | at | Nebraska | 3-31 |
| 09/17/05 | hosting | East Carolina | 44-34 |
| 09/24/05 | hosting | Maryland | 12-22 |
| 10/01/05 | hosting | Clemson | 31-27 |
| 10/08/05 | at | Florida State | 24-41 |
| 10/15/05 | at | Boston College | 30-35 |
| 10/22/05 | hosting | North Carolina State | 27-19 |
| 10/29/05 | at | Duke | 44-6 |
| 11/05/05 | at | Georgia Tech | 17-30 |
| 11/12/05 | hosting | Miami FL | 17-47 |