| 09/03/05 | at | Virginia | 19-31 |
| 09/10/05 | at | Toledo | 23-56 |
| 09/17/05 | hosting | Southern Illinois | 34-28 |
| 09/24/05 | at | Temple | 19-16 |
| 10/01/05 | hosting | Buffalo | 31-21 |
| 10/08/05 | hosting | Ball State | 57-60 5OT |
| 10/22/05 | at | Bowling Green | 45-14 |
| 10/29/05 | hosting | Kent St | 44-14 |
| 11/05/05 | at | Eastern Michigan | 44-36 |
| 11/12/05 | hosting | Central Michigan | 31-24 |
| 11/23/05 | at | Northern Illinois | 7-42 |