| 09/03/05 | hosting | Bowling Green | 56-42 |
| 09/10/05 | hosting | Temple | 65-0 |
| 09/17/05 | at | North Carolina | 14-5 |
| 09/24/05 | hosting | Michigan | 23-20 |
| 10/01/05 | hosting | Indiana | 41-24 |
| 10/08/05 | at | Northwestern | 48-51 |
| 10/15/05 | at | Minnesota | 38-34 |
| 10/22/05 | hosting | Purdue | 31-20 |
| 10/29/05 | at | Illinois | 41-24 |
| 11/05/05 | at | Penn State | 14-35 |
| 11/12/05 | hosting | Iowa | 10-20 |
| 11/25/05 | at | Hawai`i | 41-24 |
| 01/02/06 | vs. | Auburn | 0.43108510933313543 |