| 09/03/05 | at | Muskingum | 13-10 |
| 09/10/05 | hosting | MacMurray | 37-0 |
| 09/24/05 | at | Case Western Reserve | 38-21 |
| 10/01/05 | at | Allegheny | 37-34 |
| 10/08/05 | hosting | Kenyon | 21-24 |
| 10/15/05 | hosting | Wabash | 10-44 |
| 10/22/05 | at | Oberlin | 20-19 |
| 10/29/05 | hosting | Hiram | 59-17 |
| 11/05/05 | at | Wittenberg | 0-45 |
| 11/12/05 | hosting | Ohio Wesleyan | 7-21 |