| 09/01/05 | hosting | Slippery Rock | 44-14 |
| 09/10/05 | hosting | Northeastern | 35-16 |
| 09/17/05 | at | Liberty | 42-0 |
| 09/24/05 | at | Pittsburgh | 0-41 |
| 10/01/05 | hosting | Illinois St | 20-17 |
| 10/08/05 | at | Indiana State | 45-0 |
| 10/15/05 | hosting | Western Illinois | 23-21 |
| 10/22/05 | hosting | Missouri St | 31-7 |
| 10/29/05 | at | Northern Iowa | 7-21 |
| 11/05/05 | at | Southern Illinois | 17-31 |
| 11/12/05 | hosting | Western Kentucky | 42-10 |