| 09/02/06 | hosting | Eastern Illinois | 42-17 |
| 09/09/06 | at | Rutgers | 0-33 |
| 09/16/06 | hosting | Syracuse | 21-31 |
| 09/23/06 | hosting | Iowa | 7-24 |
| 09/30/06 | at | Michigan St | 23-20 |
| 10/07/06 | hosting | Indiana | 32-34 |
| 10/14/06 | hosting | Ohio U. | 17-20 |
| 10/21/06 | at | Penn State | 12-26 |
| 10/28/06 | at | Wisconsin | 24-30 |
| 11/04/06 | hosting | Ohio State | 10-17 |
| 11/11/06 | hosting | Purdue | 31-42 |
| 11/18/06 | at | Northwestern | 16-27 |