| 08/31/06 | hosting | Northwestern | 3-21 |
| 09/09/06 | at | Purdue | 31-38 OT |
| 09/16/06 | hosting | Kent St | 14-16 |
| 09/23/06 | at | Syracuse | 14-34 |
| 09/30/06 | at | Cincinnati | 10-24 |
| 10/08/06 | hosting | Northern Illinois | 25-28 |
| 10/15/06 | at | Buffalo | 38-31 |
| 10/21/06 | at | Akron | 13-24 |
| 10/28/06 | hosting | Ball St | 17-20 |
| 11/04/06 | at | Western Michigan | 24-27 |
| 11/15/06 | at | Bowling Green | 9-7 |
| 11/24/06 | hosting | Ohio U. | 24-34 |