| 09/02/06 | hosting | Idaho | 27-17 |
| 09/09/06 | hosting | Eastern Michigan | 52-20 |
| 09/16/06 | at | Pittsburgh | 38-23 |
| 09/23/06 | hosting | Notre Dame | 37-40 |
| 09/30/06 | hosting | Illinois | 20-23 |
| 10/07/06 | at | Michigan | 13-31 |
| 10/14/06 | hosting | Ohio State | 7-38 |
| 10/21/06 | at | Northwestern | 41-38 |
| 10/28/06 | at | Indiana | 21-46 |
| 11/04/06 | hosting | Purdue | 15-17 |
| 11/11/06 | hosting | Minnesota | 18-31 |
| 11/18/06 | at | Penn State | 13-17 |