| 08/31/06 | at | Kent St | 44-0 |
| 09/09/06 | at | California | 17-42 |
| 09/16/06 | hosting | Temple | 62-0 |
| 09/23/06 | at | Purdue | 21-27 |
| 09/30/06 | hosting | Michigan | 14-28 |
| 10/07/06 | hosting | Penn State | 27-28 OT |
| 10/14/06 | at | Wisconsin | 12-48 |
| 10/21/06 | hosting | North Dakota St | 10-9 |
| 10/28/06 | at | Ohio State | 0-44 |
| 11/04/06 | hosting | Indiana | 63-26 |
| 11/11/06 | at | Michigan St | 31-18 |
| 11/18/06 | hosting | Iowa | 34-24 |
| 12/29/06 | at | Texas Tech | 41-44 |