| 08/31/06 | at | Miami OH | 21-3 |
| 09/09/06 | hosting | New Hampshire | 17-34 |
| 09/16/06 | hosting | Eastern Michigan | 14-6 |
| 09/22/06 | at | Nevada | 21-31 |
| 09/30/06 | at | Penn State | 7-33 |
| 10/07/06 | at | Wisconsin | 9-41 |
| 10/14/06 | hosting | Purdue | 10-31 |
| 10/21/06 | hosting | Michigan St | 38-41 |
| 10/28/06 | at | Michigan | 3-17 |
| 11/04/06 | at | Iowa | 21-7 |
| 11/11/06 | hosting | Ohio State | 10-54 |
| 11/18/06 | hosting | Illinois | 27-16 |