| 09/02/06 | hosting | Northern Illinois | 35-12 |
| 09/09/06 | at | Texas | 24-7 |
| 09/16/06 | hosting | Cincinnati | 37-7 |
| 09/23/06 | hosting | Penn State | 28-6 |
| 09/30/06 | at | Iowa | 38-17 |
| 10/07/06 | hosting | Bowling Green | 35-7 |
| 10/14/06 | at | Michigan St | 38-7 |
| 10/21/06 | hosting | Indiana | 44-3 |
| 10/28/06 | hosting | Minnesota | 44-0 |
| 11/04/06 | at | Illinois | 17-10 |
| 11/11/06 | at | Northwestern | 54-10 |
| 11/18/06 | hosting | Michigan | 42-39 |
| 01/08/07 | hosting | Florida | 14-41 |