| 09/02/06 | hosting | Missouri St | 52-10 |
| 09/09/06 | at | Arkansas St | 35-7 |
| 09/16/06 | hosting | Florida Atlantic | 48-8 |
| 09/23/06 | at | Houston | 25-34 |
| 10/07/06 | at | Kansas St | 27-31 |
| 10/14/06 | at | Kansas | 42-32 |
| 10/21/06 | hosting | Texas A&M | 33-34 OT |
| 10/28/06 | hosting | Nebraska | 41-29 |
| 11/04/06 | at | Texas | 10-36 |
| 11/11/06 | hosting | Baylor | 66-24 |
| 11/18/06 | at | Texas Tech | 24-30 |
| 11/25/06 | hosting | Oklahoma | 21-27 |
| 12/28/06 | at | Alabama | 34-31 |