| 09/02/06 | at | Florida | 7-34 |
| 09/09/06 | hosting | SE Louisiana St | 45-0 |
| 09/16/06 | hosting | North Carolina St | 37-17 |
| 09/26/06 | at | Central Florida | 19-14 |
| 10/03/06 | at | Tulsa | 6-20 |
| 10/14/06 | hosting | Houston | 31-27 |
| 10/21/06 | at | Virginia Tech | 6-36 |
| 10/28/06 | hosting | East Carolina | 17-20 OT |
| 11/05/06 | at | Memphis | 42-21 |
| 11/11/06 | at | Tulane | 31-3 |
| 11/18/06 | hosting | Alabama-Birmingham | 25-20 |
| 11/25/06 | hosting | Marshall | 42-7 |
| 12/01/06 | at | Houston | 20-34 |
| 01/07/07 | hosting | Ohio U. | 28-7 |