| 09/02/06 | at | Wake Forest | 10-20 |
| 09/09/06 | hosting | Iowa | 13-20 2OT |
| 09/16/06 | at | Illinois | 31-21 |
| 09/23/06 | hosting | Miami OH | 34-14 |
| 09/30/06 | hosting | Wyoming | 40-34 2OT |
| 10/07/06 | hosting | Pittsburgh | 11-21 |
| 10/14/06 | at | West Virginia | 17-41 |
| 10/21/06 | hosting | Louisville | 13-28 |
| 10/28/06 | at | Cincinnati | 3-17 |
| 11/11/06 | at | South Florida | 10-27 |
| 11/18/06 | hosting | Connecticut | 20-14 |
| 11/25/06 | at | Rutgers | 7-38 |