| 08/31/06 | at | Buffalo | 3-9 OT |
| 09/09/06 | hosting | Louisville | 0-62 |
| 09/16/06 | at | Minnesota | 0-62 |
| 09/23/06 | at | Western Michigan | 7-41 |
| 09/30/06 | at | Vanderbilt | 14-43 |
| 10/07/06 | hosting | Kent St | 17-28 |
| 10/12/06 | at | Clemson | 9-63 |
| 10/21/06 | at | Northern Illinois | 21-43 |
| 10/28/06 | hosting | Bowling Green | 28-14 |
| 11/04/06 | hosting | Central Michigan | 26-42 |
| 11/11/06 | at | Penn State | 0-47 |
| 11/18/06 | at | Navy | 6-42 |